ONCOLOGY · ADVANCED SOLID TUMORS
DB-1305 advanced solid tumor study
Information about a Phase 1/2a first-in-human study for advanced or metastatic solid tumors.
Study overview
This multicenter, open-label Phase 1/2a study is evaluating DB-1305 in people with advanced or metastatic solid tumors. Listed cohorts include nonsquamous non-small cell lung cancer, mesothelioma, cervical cancer, head and neck squamous cell carcinoma, ovarian cancer, and triple-negative breast cancer. A first-in-human study introduces an investigational treatment under a carefully defined protocol. The study team confirms tumor type, disease history, pathology, and other eligibility requirements.
What the research examines
Early portions commonly evaluate safety, tolerability, dose selection, pharmacokinetics, and preliminary biological effects. Expansion portions may also assess early evidence of antitumor activity within defined cancer groups. Study procedures can include examinations, laboratory tests, imaging, tumor measurements, and monitoring for side effects. The exact visit schedule depends on the assigned cohort and protocol. DB-1305 is investigational, so its potential benefits and risks are not fully established.
Asking about participation
Eligibility may depend on cancer type, disease status, prior treatments, general health, laboratory findings, and protocol-specific tissue or biomarker requirements. Cohort availability can change as groups open, pause, fill, or close. Screening does not guarantee enrollment, and contacting California Research Institute does not obligate you to participate.
Participation is voluntary. During informed consent, the research team explains required visits, procedures, foreseeable risks, alternatives, privacy protections, and participant rights. You may review the study with your physician, family, or another trusted adviser before deciding.
For current information, call (323) 660-6200 or email trials@caresinst.org. Please do not email medical records, insurance details, or sensitive health information. This page is educational and does not replace medical advice.